Computational Research in Boston and Beyond Seminar
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Speaker: Richard Huang (MIT) Zoom link: https://mit.zoom.us/j/91933017072 Title: Modeling the Mechanics of DNA Nanostructures in Flow Abstract: Modern DNA synthesis techniques enable the precise design of heterogeneous DNA nanostructures, with proposed applications in drug delivery, vaccine development, and biosensing. In these applications, particles may encounter flow and spatially varying hydrodynamic forces. However, the relationship between designed particle structure and deformation under these non-uniform forces remains poorly understood. Understanding this relationship requires examining how shape determines force transmission and how local structural transitions enable larger-scale deformation. In this work, we combine coarse-grained molecular dynamics and mechanistic modeling, using DNA as a canonical polymeric system to investigate deformation under non-uniform forcing. We start by understanding the flow response mechanisms of simple linear and cyclic DNA chains in exten
